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Comparative approaches to facilitate the discovery of prolongevity interventions: effects to tocopherols of lifespan of three invertebrate species

Zou, Sige [autor/a] | Sinclair, Jason [autor/a] | Wilson, Mark A [autor/a] | Carey, James R [autor/a] | Liedo Fernández, Pablo [autor/a] | Oropeza Cabrera, Azucena [autor/a] | Kalra, Avash [autor/a] | de Cabo, Rafael [autor/a] | Ingram, Donald K [autor/a] | Longo, Dan L [autor/a] | Wolkow, Catherine A [autor/a].
Tipo de material: Artículo ArtículoTema(s): Tocoferoles | Vitamina E | Longevidad | Invertebrados | Drosophila melanogaster | Anastrepha ludens | Anastrepha elegans | Moscas de la frutaTema(s) en inglés: Tocopherols | Vitamin E | Longevity | Invertebrates | Drosophila melanogaster | Anastrepha ludens | Anastrepha elegans | Fruit fliesNota de acceso: Disponible para usuarios de ECOSUR con su clave de acceso En: Mechanisms of Ageing and Development. volumen 128, número 2 (February 2007), páginas 222-226Número de sistema: 46476Resumen:
Inglés

Many compounds hold promise for pharmacologic manipulation of aging. However, such claims are difficult to investigate due to time and budget constraints. Here, we took a comparative approach, using short-lived invertebrate species, to directly test the effects of two tocopherols (vitamin E) on longevity. γ-tocopherol represents the most abundant tocopherol in the Western diet, while α- tocopherol is selectively enriched in human plasma. Both isoforms demonstrate antioxidant activity and are proposed to have anti-aging activities. We compared the effects of α- and γ-tocopherol supplementation on lifespan in three invertebrate species. γ-, but not α-, tocopherol slightly extended lifespan in nematodes, but neither significantly affected lifespan in two fly species. This study shows that a comparative approach, utilizing multiple invertebrate species, can increase the robustness of invertebrate-based pilot screens for prolongevity interventions.
Lista(s) en las que aparece este ítem: Azucena Oropeza Cabrera
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Disponible para usuarios de ECOSUR con su clave de acceso

Many compounds hold promise for pharmacologic manipulation of aging. However, such claims are difficult to investigate due to time and budget constraints. Here, we took a comparative approach, using short-lived invertebrate species, to directly test the effects of two tocopherols (vitamin E) on longevity. γ-tocopherol represents the most abundant tocopherol in the Western diet, while α- tocopherol is selectively enriched in human plasma. Both isoforms demonstrate antioxidant activity and are proposed to have anti-aging activities. We compared the effects of α- and γ-tocopherol supplementation on lifespan in three invertebrate species. γ-, but not α-, tocopherol slightly extended lifespan in nematodes, but neither significantly affected lifespan in two fly species. This study shows that a comparative approach, utilizing multiple invertebrate species, can increase the robustness of invertebrate-based pilot screens for prolongevity interventions. eng

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