Population genetics / Matthew B. Hamilton

Incluye bibliografía: páginas 383-395 e índice: páginas 96-407

Contents.. Preface and acknowledgments.. 1 Thinking like a population geneticist.. 1.1 Expectations.. 1.2 Theory and assumptions.. 1.3 Simulation.. Chapter 1 review.. Further reading.. 2 Genotype frequencies.. 2.1 Mendel's model of particulate genetics.. 2.2 Hardy-Weinberg expected genotype frequencies.. 2.3 Why does Hardy-Weinberg work?.. 2.4 Applications of Hardy-Weinberg.. 2.5 The fixation index and heterozygosit.. 2.6 Mating among relatives.. 2.7 Gametic disequilibrium.. Chapter 2 review.. Further reading.. Problem box answers.. 3 Genetic drift and effective population size.. 3.1 The effects of sampling lead to genetic drift.. 3.2 Models of genetic drift.. 3.3 Effective population size.. 3.4 Parallelism between drift and inbreeding.. 3.5 Estimating effective population size.. 3.6 Gene genealogies and the coalescent model.. 3.7 Effective population size in the coalescent model.. Chapter 3 review.. Further reading.. Problem box answers.. 4 Population structure and gene flow.. 4.1 Genetic populations.. 4.2 Direct measures of gene flow.. 4.3 Fixation indices to measure the pattern of population subdivision.. 4.4 Population subdivision and the Wahlund effect.. 4.5 Models of population structure.. 4.6 The impact of population structure on genealogical branching.. Chapter 4 review.. Further reading.. Problem box answers.. 5 Mutation.. 5.1 The source of all genetic variation.. 5.2 The fate of a new mutation.. 5.3 Mutation models.. 5.4 The influence of mutation on allele frequency and autozygosity.. 5.5 The coalescent model with mutation.. Chapter 5 review.. Further reading..

6 Fundamentals of natural selection.. 6.1 Natural selection.. 6.2 General results for natural selection on a diallelic locus.. 6.3 How natural selection works to increase average fitness.. Chapter 6 review.. Further reading.. Problem box answers.. 7 Further models of natural selection.. 7.1 Viability selection with three alleles or two loci.. 7.2 Alternative models of natural selection.. 7.3 Combining natural selection with other processes.. 7.4 Natural selection in genealogical branching models.. Chapter 7 review.. Further reading.. Problem box answers.. 8 Molecular evolution.. 8.1 The neutral theory.. 8.2 Measures of divergence and polymorphism..8.3 DNA sequence divergence and the molecular clock.. 8.4 Testing the molecular clock hypothesis and explanations for rate variation in molecular evolution.. 8.5 Testing the neutral theory null model of DNA sequence evolution.. 8.6 Molecular evolution of loci that are not independent.. Chapter 8 review.. Further reading.. Problem box answers.. 9 Quantitative trait variation and evolution.. 9.1 Quantitative traits.. 9.2 Evolutionary change in quantitative traits.. 9.3 Quantitative trait loci (QTL.. Chapter 9 review.. Further reading.. Problem box answers

10 The Mendelian basis of quantitative trait variation.. 10.1 The connection between particulate inheritance and quantitative trait variation.. 10.2 Mean genotypic value in a population.. 10.3 Average effect of an allele.. 10.4 Breeding value and dominance deviation.. 10.5 Components of total genotypic variance.. 10.6 Genotypic resemblance between relatives.. Chapter 10 review.. Further reading.. Problem box answers.. 11 Historical and synthetic topics.. 11.1 Historical controversies in population genetics.. 11.2 Shifting balance theory.. Chapter 11 review.. Further reading.. Appendix.. Statistical uncertainty.. Problem box A.1 Estimating the variance.. Interact box A.1 The central limit theorem.. Covariance and correlation.. Further reading.. Problem box answers.. References.. Index

This book aims to make population genetics approachable, logical and easily understood. To achieve these goals, the book's design emphasizes well explained introductions to key principles and predictions. These are augmented with case studies as well as illustrations along with introductions to classical hypotheses and debates. Pedagogical features in the text include: Interact boxes that guide readers step-by-step through computer simulations using public domain software. Math boxes that fully explain mathematical derivations. Methods boxes that give insight into the use of actual genetic data. Numerous Problem boxes are integrated into the text to reinforce concepts as they are encountered. This text also offers a highly accessible introduction to coalescent theory, the major conceptual advance in population genetics of the last two decades. The book es accompanied by a companion website with interactive computer simulations for each chapter, designed to animate the fundamental concepts of population genetics: www.wiley.com/go/hamiltongenetics eng