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Mapping knowledge translation and innovation processes in cancer drug development : the case of liposomal doxorubicin

Tipo de material: Artículo
 en línea Artículo en línea Idioma: Inglés Tema(s) en español: Tema(s) en inglés: Recurso en línea: En: Journal of Translational Medicine Volumen 12 (September 2014)Nota de acceso: Acceso en línea sin restricciones Resumen:
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We explored how the knowledge translation and innovation processes are structured when theyresult in innovations, as in the case of liposomal doxorubicin research. In order to map the processes, a literature network analysis was made through Cytoscape and semantic analysis was performed by GOPubmed which is based in the controlled vocabularies MeSH (Medical Subject Headings) and GO (Gene Ontology). We found clusters related to different stages of the technological development (invention, innovation and imitation) and the knowledge translation process (preclinical, translational and clinical research), and we were able to map the historic emergence of Doxil as a paradigmatic nanodrug. This research could be a powerful methodological tool for decision-making and innovation management in drug delivery research.

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Artículos Biblioteca Electrónica Recursos en línea (RE) ECOSUR Recurso digital ECO400003325115

Acceso en línea sin restricciones

We explored how the knowledge translation and innovation processes are structured when theyresult in innovations, as in the case of liposomal doxorubicin research. In order to map the processes, a literature network analysis was made through Cytoscape and semantic analysis was performed by GOPubmed which is based in the controlled vocabularies MeSH (Medical Subject Headings) and GO (Gene Ontology). We found clusters related to different stages of the technological development (invention, innovation and imitation) and the knowledge translation process (preclinical, translational and clinical research), and we were able to map the historic emergence of Doxil as a paradigmatic nanodrug. This research could be a powerful methodological tool for decision-making and innovation management in drug delivery research. Inglés