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Mapping knowledge translation and innovation processes in cancer drug development: the case of liposomal doxorubicin

Fajardo Ortiz, David Guillermo [autor] | Durán, Luis [autor] | Moreno Altamirano, Laura [autora] | Ochoa Díaz López, Héctor [autor] | Castaño Meneses, Víctor Manuel [autor].
Tipo de material: Artículo en línea Artículo en línea Tema(s): Doxorubicina liposomal | Liposomas | Neoplasmas | NanomedicinaTema(s) en inglés: Liposomal doxorubicin | Liposomes | Neoplasms | NanomedicineNota de acceso: Acceso en línea sin restricciones En: Journal of Translational Medicine. Volumen 12 (September 2014). --ISSN: 1479-5876Número de sistema: 332Resumen:
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We explored how the knowledge translation and innovation processes are structured when theyresult in innovations, as in the case of liposomal doxorubicin research. In order to map the processes, a literature network analysis was made through Cytoscape and semantic analysis was performed by GOPubmed which is based in the controlled vocabularies MeSH (Medical Subject Headings) and GO (Gene Ontology). We found clusters related to different stages of the technological development (invention, innovation and imitation) and the knowledge translation process (preclinical, translational and clinical research), and we were able to map the historic emergence of Doxil as a paradigmatic nanodrug. This research could be a powerful methodological tool for decision-making and innovation management in drug delivery research.

Recurso en línea: http://www.translational-medicine.com/content/pdf/s12967-014-0227-9.pdf
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Acceso en línea sin restricciones

We explored how the knowledge translation and innovation processes are structured when theyresult in innovations, as in the case of liposomal doxorubicin research. In order to map the processes, a literature network analysis was made through Cytoscape and semantic analysis was performed by GOPubmed which is based in the controlled vocabularies MeSH (Medical Subject Headings) and GO (Gene Ontology). We found clusters related to different stages of the technological development (invention, innovation and imitation) and the knowledge translation process (preclinical, translational and clinical research), and we were able to map the historic emergence of Doxil as a paradigmatic nanodrug. This research could be a powerful methodological tool for decision-making and innovation management in drug delivery research. eng

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