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Comparative estimates of crude and effective coverage of measles immunization in low-resource settings: findings from salud Mesoamérica 2015

Colson, Katherine Ellicott [autora] | Zúñiga Brenes, Paola [autora] | Ríos Zertuche, Diego [autor] | Conde González, Carlos J [autor] | Gagnier, Marielle C [autora] | Palmisano, Erin B [autor] | Ranganathan, Dharani [autor] | Usmanova, Gulnoza [autor] | Salvatierra Izaba, Ernesto Benito [autor] | Nazar Beutelspacher, Austreberta, 1960- [autora] | Tristao, Ignez [autor] | Sánchez Monin, Emmanuelle [autor] | Anderson, Brent W [autor] | Haakenstad, Annie [autora] | Murphy, Tasha [autora] | Lim, Stephen [autor] | Hernández, Bernardo [autor] | Lozano, Rafael [autor] | Iriarte, Emma [autora] | Mokdad, Ali H [autora].
Tipo de material: Artículo en línea Artículo en línea Tema(s): Vacuna contra el sarampión | Programas de inmunización | Salud infantil | Salud maternoinfantil | Servicios de saludTema(s) en inglés: Measles vaccine | Immunization programs | Child health | Maternal and child health | Medical careDescriptor(es) geográficos: Chiapas (México) | Jinotega (Nicaragua) Nota de acceso: Acceso en línea sin restricciones En: PLoS ONE. volumen 10, número 7, e0130697 (July 2015), páginas 1-21. --ISSN: 1932-6203Número de sistema: 3241Resumen:
Inglés

Timely and accurate measurement of population protection against measles is critical for decision-making and prevention of outbreaks. However, little is known about how surveybased estimates of immunization (crude coverage) compare to the seroprevalence of antibodies (effective coverage), particularly in low-resource settings. In poor areas of Mexico and Nicaragua, we used household surveys to gather information on measles immunization from child health cards and caregiver recall. We also collected dried blood spots (DBS) from children aged 12 to 23 months to compare crude and effective coverage of measles immunization. We used survey-weighted logistic regression to identify individual, maternal, household, community, and health facility characteristics that predict gaps between crude coverage and effective coverage. We found that crude coverage was significantly higher than effective coverage (83% versus 68% in Mexico; 85% versus 50% in Nicaragua). A large proportion of children (19% in Mexico; 43% in Nicaragua) had health card documentation of measles immunization but lacked antibodies. These discrepancies varied from 0% to 100% across municipalities in each country. In multivariate analyses, card-positive children in Mexico were more likely to lack antibodies if they resided in urban areas or the jurisdiction of De Los Llanos. In contrast, card-positive children in Nicaragua were more likely to lack antibodies if they resided in rural areas or the North Atlantic region, had low weight-for-age, or attended health facilities with a greater number of refrigerators. Findings highlight that reliance on child health cards to measure population protection against measles is unwise.

We call for the evaluation of immunization programs using serological methods, especially in poor areas where the cold chain is likely to be compromised. Identification of within-country variation in effective coverage of measles immunization will allow researchers and public health professionals to address challenges in current immunization programs.

Recurso en línea: http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0130697&representation=PDF
Lista(s) en las que aparece este ítem: Austreberta Nazar Beutelspacher
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Acceso en línea sin restricciones

Timely and accurate measurement of population protection against measles is critical for decision-making and prevention of outbreaks. However, little is known about how surveybased estimates of immunization (crude coverage) compare to the seroprevalence of antibodies (effective coverage), particularly in low-resource settings. In poor areas of Mexico and Nicaragua, we used household surveys to gather information on measles immunization from child health cards and caregiver recall. We also collected dried blood spots (DBS) from children aged 12 to 23 months to compare crude and effective coverage of measles immunization. We used survey-weighted logistic regression to identify individual, maternal, household, community, and health facility characteristics that predict gaps between crude coverage and effective coverage. We found that crude coverage was significantly higher than effective coverage (83% versus 68% in Mexico; 85% versus 50% in Nicaragua). A large proportion of children (19% in Mexico; 43% in Nicaragua) had health card documentation of measles immunization but lacked antibodies. These discrepancies varied from 0% to 100% across municipalities in each country. In multivariate analyses, card-positive children in Mexico were more likely to lack antibodies if they resided in urban areas or the jurisdiction of De Los Llanos. In contrast, card-positive children in Nicaragua were more likely to lack antibodies if they resided in rural areas or the North Atlantic region, had low weight-for-age, or attended health facilities with a greater number of refrigerators. Findings highlight that reliance on child health cards to measure population protection against measles is unwise. eng

We call for the evaluation of immunization programs using serological methods, especially in poor areas where the cold chain is likely to be compromised. Identification of within-country variation in effective coverage of measles immunization will allow researchers and public health professionals to address challenges in current immunization programs. eng

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