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Immunomodulating and antitumor properties of Pleurotus sp. in Cuba

Morris Quevedo, Humberto Joaquin [autor] | Llauradó, Gabriel [autor] | Beltrán Delgado, Yaixa [autora] | Lebeque, Yamila [autora] | Batista, Pedro L [autor] | Moukha, Serge [autor] | Perraud Gaime, Isabelle [autora] | García, Nora [autora] | Bermúdez Savón, Rosa Catalina [autora] | Bidart de Macedo, Maíra [autora] | Paul Cos, About [autor] | Hernández, Edgar [autor] | Díez Ballesteros, José C [autor].
Tipo de material: Capítulo de libro impreso(a) Capítulo de libro impreso(a) Tipo de contenido: Texto Tipo de medio: Computadora Tipo de portador: Recurso en líneaTema(s): Pleurotus | Antineoplásicos | Actividad antioxidante | Hongos medicinales | Hongos comestiblesTema(s) en inglés: Pleurotus | Antineoplastic agents | Antioxidant activity | Medicinal fungi | Edible musroomsDescriptor(es) geográficos: Cuba Nota de acceso: Acceso en línea sin restricciones Nota general: Para consultar el capítulo impreso véase el libro con la clasificación EE 635.8 U6, en SIBE-Campeche, SIBE-San Cristóbal, SIBE-Tapachula En: Updates on tropical mushrooms. Basic and applied research / José E. Sánchez, Gerardo Mata and Daniel J. Royse, editors. San Cristóbal de Las Casas, Chiapas, México: El Colegio de la Frontera Sur, 2018. páginas 159-180. --ISBN: 978-607-8429-60-8Número de sistema: 61231Resumen:
Inglés

In this chapter, we report on the effects of Pleurotus (oyster mushroom) extracts (Myc-E and FB-E) and powders (FB-P) on immunodeficient BALB/c mice. The anti-proliferative effect on NB4 human leukemia cells was measured by flow-cytometry. In addition, antioxidant activity was investigated by scavenging of DPPH and ABTS radicals, reducing power and inhibition of lipid peroxidation. Pleurotus mycelial extract (Myc-E) exerted a protective effect in both cyclophosphamide and whole-body irradiated mice in terms of bone marrow cellularity, white blood cell counts and enhancement of the monocyte-macrophage system. Cyclophosphamide treated mice also showed a stimulant effect on cell immune response when administered with fruiting body powder (FB-P). Fruit body-derived extract (FB-E) stimulated immunonutritional recovery of malnourished mice after activation of gut-associated lymphoid tissues. Myc-E reduced viability of NB4 leukemia cells, particularly at a concentration of 200 μg/ml, by arresting cells in the G2/M phase. At 10 mg/ml, FB-E showed scavenging effects for DPPH and ABTS radicals (90.4% and 80%, respectively) and inhibited lipid peroxidation (51.2%), whereas at 5 mg/ml manifested a reducing power of 0.438. Pleurotus derived-products could be considered good candidates for developing nutraceuticals and innovative myco-therapeutics, as judged by their immunomodulating/antitumor and antioxidant effects.
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Ediciones ECOSUR (EE) 		Acervo General EE 635.8 U6 Disponible
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Ediciones ECOSUR (EE) 		Acervo General EE 635.8 U6 Disponible

Para consultar el capítulo impreso véase el libro con la clasificación EE 635.8 U6, en SIBE-Campeche, SIBE-San Cristóbal, SIBE-Tapachula

Acceso en línea sin restricciones

In this chapter, we report on the effects of Pleurotus (oyster mushroom) extracts (Myc-E and FB-E) and powders (FB-P) on immunodeficient BALB/c mice. The anti-proliferative effect on NB4 human leukemia cells was measured by flow-cytometry. In addition, antioxidant activity was investigated by scavenging of DPPH and ABTS radicals, reducing power and inhibition of lipid peroxidation. Pleurotus mycelial extract (Myc-E) exerted a protective effect in both cyclophosphamide and whole-body irradiated mice in terms of bone marrow cellularity, white blood cell counts and enhancement of the monocyte-macrophage system. Cyclophosphamide treated mice also showed a stimulant effect on cell immune response when administered with fruiting body powder (FB-P). Fruit body-derived extract (FB-E) stimulated immunonutritional recovery of malnourished mice after activation of gut-associated lymphoid tissues. Myc-E reduced viability of NB4 leukemia cells, particularly at a concentration of 200 μg/ml, by arresting cells in the G2/M phase. At 10 mg/ml, FB-E showed scavenging effects for DPPH and ABTS radicals (90.4% and 80%, respectively) and inhibited lipid peroxidation (51.2%), whereas at 5 mg/ml manifested a reducing power of 0.438. Pleurotus derived-products could be considered good candidates for developing nutraceuticals and innovative myco-therapeutics, as judged by their immunomodulating/antitumor and antioxidant effects. eng

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