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Biodegradation of NSAIDs and their effect on the activity of ligninolytic enzymes from Pleurotus djamor

Cruz Ornelas, Rosbi | Sánchez, José E [autor/a] | Amaya Delgado, Lorena [autor/a] | Guillén Navarro, Griselda Karina [autor/a] | Calixto Romo, Angeles [autor/a].
Tipo de material: Artículo en línea Artículo en línea Tema(s): Pleurotus djamor | Biodegradación | Diclofenaco | Naproxeno | Ketoprofeno | Enzimas ligninolíticas | EnzimologíaTema(s) en inglés: Pleurotus djamor | Biodegradation | Diclofenac | Naproxen | Ketoprofen | Ligninolytic enzymes | EnzymologyNota de acceso: Acceso en línea sin restricciones En: 3 Biotech. volumen 9, no 10, 373 (October 2019), páginas 1-8. --ISSN: 2190-5738Número de sistema: 59658Resumen:
Inglés

In this work, the white-rot fungus Pleurotus djamor was used for the first time to determine the degradation kinetics of the nonsteroidal anti-inflammatory drugs diclofenac, naproxen and, ketoprofen, either individually or in mixtures, in submerged cultures. Removal of 93% individual diclofenac and 99% diclofenac in mixtures with naproxen and ketoprofen at 6 h of incubation with the fungus was achieved. The elimination levels of naproxen and ketoprofen individually were 90% and 87%, respectively, after 48 h of incubation. However, the removal levels of these compounds in mixtures were 85% and 83%, respectively. On the other hand, during the degradation kinetics analysis, the enzymatic activities of laccases, manganese peroxidases, and lignin peroxidases were evaluated, yielding values of 3700, 270 and 31 U/L, respectively. Additionally, it was demonstrated that during degradation of diclofenac or the three drugs mixed in the submerged cultures, the enzymatic activity of extracellular laccases expressed by P. djamor increased by 200% and 300%, respectively. The activity of manganese peroxides increased by 126% with diclofenac and 138% when the mixture of drugs was added to the cultures. On the other hand, lignin peroxidase only increased activity by 123% with the drug mixture.

Recurso en línea: https://link.springer.com/article/10.1007%2Fs13205-019-1904-4
Lista(s) en las que aparece este ítem: José Ernesto Sánchez Vázquez
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Acceso en línea sin restricciones

In this work, the white-rot fungus Pleurotus djamor was used for the first time to determine the degradation kinetics of the nonsteroidal anti-inflammatory drugs diclofenac, naproxen and, ketoprofen, either individually or in mixtures, in submerged cultures. Removal of 93% individual diclofenac and 99% diclofenac in mixtures with naproxen and ketoprofen at 6 h of incubation with the fungus was achieved. The elimination levels of naproxen and ketoprofen individually were 90% and 87%, respectively, after 48 h of incubation. However, the removal levels of these compounds in mixtures were 85% and 83%, respectively. On the other hand, during the degradation kinetics analysis, the enzymatic activities of laccases, manganese peroxidases, and lignin peroxidases were evaluated, yielding values of 3700, 270 and 31 U/L, respectively. Additionally, it was demonstrated that during degradation of diclofenac or the three drugs mixed in the submerged cultures, the enzymatic activity of extracellular laccases expressed by P. djamor increased by 200% and 300%, respectively. The activity of manganese peroxides increased by 126% with diclofenac and 138% when the mixture of drugs was added to the cultures. On the other hand, lignin peroxidase only increased activity by 123% with the drug mixture. eng

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