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Quercetin regulates key components of the cellular microenvironment during early hepatocarcinogenesis

Reyes Avendaño, Itayetzi [autora] | Reyes Jiménez, Edilburga [autora] | González García, Karina [autora] | [Pérez Figueroa, Dulce Carolina, autora] | Baltiérrez Hoyos, Rafael [autor] | Tapia Pastrana, Gabriela [autora] | Sánchez Chino, Xariss Miryam [autor] | Villa Treviño, Saúl [autor] | Arellanes Robledo, Jaime [autor] | Vásquez Garzón, Verónica Rocío [autora].
Tipo de material: Artículo en línea Artículo en línea Tipo de contenido: Texto Tipo de medio: Computadora Tipo de portador: Recurso en líneaTema(s): Carcinoma hepatocelular | Quercetina | Anticarcinógenos | Microambiente tumoral | HepatocarcinogénesisTema(s) en inglés: Hepatocellular carcinoma | Quercetin | Anticarcinogenic agents | Tumor microenvironmen | HepatocarcinogenesisNota de acceso: Disponible para usuarios de ECOSUR con su clave de acceso En: Antioxidants. Volumen 11, número 2, 358 (February 2022), páginas 1-18. --ISSN: 2076-3921Número de sistema: 33140Resumen:
Inglés

Hepatocellular carcinoma (HCC) is a health problem worldwide due to its high mortality rate, and the tumor microenvironment (TME) plays a key role in the HCC progression. The current ineffective therapies to fight the disease still warrant the development of preventive strategies. Quercetin has been shown to have different antitumor activities; however, its effect on TME components in preneoplastic lesions has not been fully investigated yet. Here, we aimed to evaluate the effect of quercetin (10 mg/kg) on TME components during the early stages of HCC progression induced in the rat. Histopathological and immunohistochemical analyses showed that quercetin decreases the size of preneoplastic lesions, glycogen and collagen accumulation, the expression of cancer stem cells and myofibroblasts markers, and that of the transporter ATP binding cassette subfamily C member 3 (ABCC3), a marker of HCC progression and multidrug resistance. Our results strongly suggest that quercetin has the capability to reduce key components of TME, as well as the expression of ABCC3. Thus, quercetin can be an alternative treatment for inhibiting the growth of early HCC tumors.

Recurso en línea: https://www.mdpi.com/2076-3921/11/2/358
Lista(s) en las que aparece este ítem: Mujeres en la ciencia-ECOSUR Villahermosa
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Disponible para usuarios de ECOSUR con su clave de acceso

Hepatocellular carcinoma (HCC) is a health problem worldwide due to its high mortality rate, and the tumor microenvironment (TME) plays a key role in the HCC progression. The current ineffective therapies to fight the disease still warrant the development of preventive strategies. Quercetin has been shown to have different antitumor activities; however, its effect on TME components in preneoplastic lesions has not been fully investigated yet. Here, we aimed to evaluate the effect of quercetin (10 mg/kg) on TME components during the early stages of HCC progression induced in the rat. Histopathological and immunohistochemical analyses showed that quercetin decreases the size of preneoplastic lesions, glycogen and collagen accumulation, the expression of cancer stem cells and myofibroblasts markers, and that of the transporter ATP binding cassette subfamily C member 3 (ABCC3), a marker of HCC progression and multidrug resistance. Our results strongly suggest that quercetin has the capability to reduce key components of TME, as well as the expression of ABCC3. Thus, quercetin can be an alternative treatment for inhibiting the growth of early HCC tumors. eng

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