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White rot fungi are known for their highly efficient ability to degrade environmental pollutants, such as pharmaceuticals. We investigated the ability of enzymatic extracts from Auricularia fuscosuccinea, Lentinula edodes, Ganoderma lucidum, Agrocybe aegerita, Pleurotus ostreatus, P. djamor and P. eryngii to degrade the analgesic drug metamizole. The formation of 4-MAA and 4-AA metabolites was also monitored. Total degradation of 50 mg l-1 of the drug was achieved with the extract obtained from A. fuscosuccinea ECS-210 within three days. Under the best conditions (pH 5.6, 35 °C and 110 rpm), the degradation profile followed the behavior of pseudo-first order kinetics with a coefficient k = 0.0779 L mg-1h-1. The enzymatic activity tests showed evidence for the presence of laccases, lignin peroxidases and phenoloxidases. Inglés