Evolution and spread of Venezuelan equine encephalitis complex alphavirus in the Americas
Forrester, Naomi L [autora] | Wertheim, Joel O [autor] | Dugan, Vivian G [autora] | Auguste, Albert J [autor] | Lin, David [autor] | Adams, A. Paige [autora] | Chen, Rubing [autora] | Gorchakov, Rodion [autor] | Leal, Grace [autora] | Estrada Franco, José G [autor] | Pandya, Jyotsna [autora] | Halpin, Rebecca A [autora] | Hari, Kumar [autor] | Jain, Ravi [autor] | Stockwell, Timothy B [autor] | Das, Suman R [autor] | Wentworth, David E [autor] | Smith, Martin D [autor] | Kosakovsky Pond, Sergei L [autor] | Weaver, Scott C [autor].
Tipo de material: Artículo en línea Tema(s): Virus de la encefalitis equina venezolana | Virus | Filogenética | Endemia | Análisis genéticoTema(s) en inglés: Venezuelan encephalitis virus | Viruses | Phylogenetics | Endemics | Genetic analysis | North AmericaDescriptor(es) geográficos: América del Norte | América Central Nota de acceso: Acceso en línea sin restricciones En: PLOS Neglected Tropical Diseases. volumen 11, número 8, e0005693 (2017), páginas 1-19. --ISSN: 1935-2735Número de sistema: 59324Resumen:Tipo de ítem | Biblioteca actual | Colección | Signatura | Estado | Fecha de vencimiento | Código de barras |
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Artículos | Biblioteca Electrónica Recursos en línea (RE) | ECOSUR | Recurso digital | ECO400593242563 |
Acceso en línea sin restricciones
Venezuelan equine encephalitis (VEE) complex alphaviruses are important re-emerging arboviruses that cause life-threatening disease in equids during epizootics as well as spillover human infections. We conducted a comprehensive analysis of VEE complex alphaviruses by sequencing the genomes of 94 strains and performing phylogenetic analyses of 130 isolates using complete open reading frames for the nonstructural and structural polyproteins. Our analyses confirmed purifying selection as a major mechanism influencing the evolution of these viruses as well as a confounding factor in molecular clock dating of ancestors. Times to most recent common ancestors (tMRCAs) could be robustly estimated only for the more recently diverged subtypes; the tMRCA of the ID/IAB/IC/II and IE clades of VEE virus (VEEV) were estimated at ca. 149-973 years ago. Evolution of the IE subtype has been characterized by a significant evolutionary shift from the rest of the VEEV complex, with an increase in structural protein substitutions that are unique to this group, possibly reflecting adaptation to its unique enzootic mosquito vector Culex (Melanoconion) taeniopus. Our inferred tree topologies suggest that VEEV is maintained primarily in situ, with only occasional spread to neighboring countries, probably reflecting the limited mobility of rodent hosts and mosquito vectors. eng
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