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The effect of ivermectin treatment on the antibody response to antigens of Onchocerca volvulus

Guillespie, Adan J [autor] | Lugstigman, A. R [autor/a] | Rivas Alcalá, Adrián Roberto [autor] | Bradley, J. E [autor/a].
Tipo de material: Artículo impreso(a) y electrónico Artículo impreso(a) y electrónico Tipo de contenido: texto Tipo de medio: computadora Tipo de portador: recurso en líneaTema(s): Onchocerca volvulus | Ivermectina | Microfilarias | Control de nemátodosTema(s) en inglés: Onchocerca volvulus | Ivermectin | Microfilariae | Nematode controlDescriptor(es) geográficos: Chiapas (México) En: Transactions of the Royal Society of Tropical Medicine and Hygiene. Volumen 88, número 4 (July-August 1994), páginas 456-460Número de sistema: 54279Resumen:
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The effect of the microfilaricidal drug ivermectin on the antibody response to a detergent extract of adult Onchocerca volvulus (OvAg) and a number of specific recombinant peptides was examined. Three of the peptides were combined in a serodiagnostic 'cocktail' and the effect of ivermectin on the diagnostic performance of this assay was assessed. Immunoglobulin (Ig) G1 serum levels in response to OvAg significantly decreased following ivermectin treatment. The antibody response to only one recombinant peptide (OvMBP29) was significantly affected, with IgG levels decreasing following treatment. Levels of total IgE increased following treatment. No correlation was observed between initial antibody level (or change in antibody level) and any adverse reaction to treatment. The serodiagnostic 'cocktail' was 100% sensitive before and after the use of ivermectin. A serodiagnostic assay using specific recombinant peptides can be used to evaluate infection in the absence of dermal microfilariae in areas where ivermectin is used

Recurso en línea: https://doi.org/10.1016/0035-9203(94)90433-2
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The effect of the microfilaricidal drug ivermectin on the antibody response to a detergent extract of adult Onchocerca volvulus (OvAg) and a number of specific recombinant peptides was examined. Three of the peptides were combined in a serodiagnostic 'cocktail' and the effect of ivermectin on the diagnostic performance of this assay was assessed. Immunoglobulin (Ig) G1 serum levels in response to OvAg significantly decreased following ivermectin treatment. The antibody response to only one recombinant peptide (OvMBP29) was significantly affected, with IgG levels decreasing following treatment. Levels of total IgE increased following treatment. No correlation was observed between initial antibody level (or change in antibody level) and any adverse reaction to treatment. The serodiagnostic 'cocktail' was 100% sensitive before and after the use of ivermectin. A serodiagnostic assay using specific recombinant peptides can be used to evaluate infection in the absence of dermal microfilariae in areas where ivermectin is used eng

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