Bioinformatics and functional genomics / Jonathan Pevsner

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Glosario: páginas 891-908

Contents in Brief.. Preface to the Second Edition.. Preface to the First Edition.. Foreword.. PART I ANALYZING DNA, RNA, AND PROTEIN SEQUENCES IN DATABASES.. 1 Introduction.. 2 Access to Sequence Data and Literature Information.. 3 Pairwise Sequence Alignment.. 4 Basic Local Alignment Search Tool (BLAST.. 5 Advanced Database Searching.. 6 Multiple Sequence Alignment.. 7 Molecular Phylogeny and Evolution.. PART II GENOMEWIDE ANALYSIS OF RNA AND PROTEIN.. 8 Bioinformatic Approaches to Ribonucleic Acid (RNA.. 9 Gene Expression: Microarray Data Analysis.. 10 Protein Analysis and Proteomics.. 11 Protein Structure.. 12 Functional Genomics.. PART III GENOME ANALYSIS.. 13 Completed Genomes.. 14 Completed Genomes: Viruses.. 15 Completed Genomes: Bacteria and Archaea.. 16 The Eukaryotic Chromosome.. 17 Eukaryotic Genomes: Fungi.. 18 Eukaryotic Genomes: From Parasites to Primates.. 19 Human Genome.. 20 Human Disease.. Glossary.. Answers to Self-Test Quizzes.. Author Index.. Subject Index

Widely received in its previous edition, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded Second Edition, it continues to be the go-to source for students and professionals involved in biomedical research. This edition provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include: -Several fundamentally important proteins, such as globins, histones, insulin, and albumins, are included to better show how to apply bioinformatics tools to basic biological questions. -A completely updated companion web site, which will be updated as new information becomes available - visit www.wiley.com/go/pevsnerbioinformatics -Descriptions of genome sequencing projects spanning the tree of life. -A stronger focus on how bioinformatics tools are used to understand human disease. The book is complemented by lavish illustrations and more than 500 figures and tables-fifty of which are entirely new to this edition. Each chapter includes a Problem Set, Pitfalls, Boxes explaining key techniques and mathematics/statistics principles, Summary, Recommended Reading, and a list of freely available software. Bioinformatics and Functional Genomics, Second Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases. eng